Anti-trypanosomal activity of crude and nano-conjugated ethanol stem bark extracts of Sterculia setigera in mice

This study was carried out to screen for anti-trypanosomal activities of Sterculia setigera crude and nano-conjugated ethanol extracts synthesized gold nanoparticles (AuNPs). Fresh stem bark S. separately extracted with (ES) aqueous (AS) followed by green synthesis/reduction extract AuNPs, its formulation into nano-conjugate the addition standard drug Diminazine aceturate (berenil). The AuNPs were also characterized. Both administered toTrypanosoma brucei infected animals orally at 200mg/kg bodyweight 12 consecutive days. Two separate groups untreated treated (Berenil) serve as positive negative controls respectively. Similarly nano conjugates satigera conjugate aceturate(berenil). Trypanosoma at200mg/kg nanoconjugates berenil different rats days consecutively. Theresults showed that group recorded significant decrease in parasitaemia than when compared controlgroups (p<0.05). Furthermore, treatment both effectively cleared parasites from blood circulation animal Bodyweight PCV improved significantly all ofS. exhibited trypanostatic activity while trypanocidal.